Oklahoma vs Michigan picks, predictions, odds for Week 2 game Saturday

The Oklahoma Sooners and Michigan Wolverines play on Saturday, Sept. 12, 2026, at Michigan Stadium in Ann Arbor, Michigan, in a game on the college football Week 2 schedule. Which team will win the college football Week 2 game? Check out these college football Week 2 picks and college football Week 2 predictions for the game, which can be seen at 9 a.m. MST on FOX (stream with FUBO). Oklahoma is a 5.5-point favorite over Michigan in college football Week 2 odds for the game, according to BetMGM Sportsbook. The Sooners are -225 on the moneyline, while the Wolverines are +185. The over/under (point total) for the game is set at 43.5 points. Mike Spector writes: "Michigan failed to deliver for spread bettors last week, as it garnered at least 76% of the spread wagers at BetMGM and DraftKings. But this week's number drifted massively from the lookahead line, and I'll be seeking to take advantage of the bigger number, with the home underdogs getting nearly a touchdown. Right now, FanDuel has the best line." Bill Speros writes: "The Big House hosted the Big Heist last week. Michigan traveled through time and pulled off an epic 'Steal Mary' against Western Michigan. The Sooner Schooner rolls into Ann Arbor, and Michigan may need 5 or 6 cracks at the ball after time expires to beat Oklahoma. Brent Venables' defense is the best unit on this field, and it will handle UM at least as well as WMU did. Meanwhile, OU should adopt Barry Switzer's playbook from the 1970s and run the Wishbone option to grind down UM early and often. But OU QB Jon Mateer will find the end zone at least twice." It writes: "After extensive simulations, our model gives Oklahoma a win probability of 61%, while Michigan has a win probability of 39%." The site gives the Wolverines a 35.6% shot at winning the college football Week 2 game. The site's formula predicts that the Sooners will beat the Wolverines in the Week 2 college football game. Iain MacMillan writes: "Bryce Underwood completed just 12-of-22 passes for 170 yards, one touchdown, and an interception. The Wolverines' running back, Jordan Marshall, recorded just 44 yards, averaging only 4.0 yards per rush. Meanwhile, the Sooners' offense record 401 yards and 51 points while shutting out the UTEP offense. Let's not get cute with this bet. It's time to lay the points with the Sooners." Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff. Support local journalism: Subscribe to azcentral.com today. Sign up for azcentral Preps Now. And be sure to subscribe to our daily sports newsletters so you don't miss a thing. Our editors independently choose our recommendations. Some content is produced with paid support from a third party, however our editorial decisions remain independent. If you buy through our links, the USA TODAY Network may earn a commission. Prices and availability may change. 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