Commanders vs. Eagles Prediction, Odds, Spread, Injuries, Trends for NFL Week 1

The Philadelphia Eagles came up short in their Super Bowl defense in 2025, losing to the San Francisco 49ers in the opening round of the playoffs. They'll look to get back to being Super Bowl contenders in their first year without A.J. Brown in 2026. Meanwhile, the Washington Commanders were on the cusp of being the kings of the NFC two years ago, but then a disastrous 2025 campaign left them back where they started. The two teams will face off in an NFC East rivalry matchup on Sunday of Week 1. Let's dive into everything you need to know to bet on this game. Commanders vs. Eagles Odds, Spread, and Total Odds via FanDuel Sportsbook Spread Commanders +5.5 (-115) Eagles -5.5 (-105) Moneyline Commanders +194 Eagles -235 Total OVER 44.5 (-112) UNDER 44.5 (-108) Commanders vs. Eagles How to Watch Date: Sunday, September 13 Time: 4:25 PM ET Venue: Lincoln Financial Field How to Watch (TV): FOX Commanders record: 0-0 Eagles record: 0-0 Commanders vs. Eagles Betting Trends The Commanders are 5-4-1 against the spread in their last 10 games vs. the Eagles The OVER is 7-3 in the last 10 meetings between these two teams The Commanders went 4-6 against the spread in their last 10 games of the 2025 season The UNDER went 8-2 in the Eagles' last 10 games of the 2025 season Commanders vs. Eagles Key Player to Watch Jayden Daniels, QB - Washington Commanders The Washington Commanders selected Jayden Daniels out of LSU with the No. 2 overall pick in the 2024 NFL Draft. He went on to have a historic rookie season, winning Offensive Rookie of the Year and finishing seventh in MVP voting en route to leading the Commanders to the NFC Championship Game. Many people believed he'd build off that season in 2025, but things dropped off in a disastrous season. He suffered an injury, appearing in just seven games, and he looked like a shell of his rookie self in those seven starts. Commanders fans are hoping he returns to his 2024 form now that he's healthy and ready to start his third NFL season. Commanders vs. Eagles Prediction and Best Bet In this week's edition of the Road to 272 Bets, I broke down why I'm taking the points with the Commanders: While I still believe the Eagles are the team to beat in the NFC East this season, there are still some things they have to prove to me before I'm ready to lay points on them. First of all, can they find a way to replace A.J. Brown's production at wide receiver with him now in New England? Also, I can't mention the Bears' record in one-score games without mentioning that the Eagles had an even better record in one-score games at 8-4. Meanwhile, the Washington Commanders have filled some holes on their roster and are much healthier than they were a year ago. They need Jayden Daniels to get back to his 2024 form, but entering this season healthy should go a long way toward doing that. I'm going to take the points with Washington. Pick: Commanders +5.5 (-115) via FanDuel Follow Iain on X and Instagram Create a new FanDuel Sportsbook account, and you can get up to $1,000 in bonus bets. Register now and make a $5 wager each day for five days to claim your FanDuel promo code offer today. Odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER. You can check out all of Iain's bets here! Add us as a preferred source on Google