Chicago Cubs at Milwaukee Brewers odds, picks and predictions

June 26, 2026, 9:31 a.m. ET The Chicago Cubs (44-37) and Milwaukee Brewers (49-29) clash in a NL Central rivalry showdown, as they swing into a 3-game series Friday. The first pitch from American Family Field in Milwaukee, Wisconsin, is slated for 7:45 p.m. ET (Apple TV). Let's analyze MLB odds around the Cubs vs. Brewers odds and make our expert MLB picks and predictions for the best bets. Season series: Milwaukee leads 3-0 The Cubs have won 4 straight games and 6 of their last 7. The 4 straight victories came in a road set at the New York Mets which concluded Thursday. Chicago -- which was ousted by the Brewers 3-2 in a 2025 NL Division Series -- is 7-1 over its last 8 road tilts. Milwaukee has also won 4 in a row; the Brewers are back in Cream City after a road swing that finished up with the club sweeping Monday-Wednesday games at the Cincinnati Reds. Milwaukee was idle Thursday. Cubs at Brewers projected starters RHP Colin Rea vs. RHP Jacob Misiorowski Rea (5-5, 4.99 ERA) is making his 13th start and 17th appearance. He owns a 1.40 WHIP, 3.2 BB/9 and 6.7 K/9 in 79 1/3 innings. Last start: No-decision, 5 1/3 IP, 0 ER, 3 H, 0 BB, 3 K in 8-6 loss vs. Toronto Blue Jays Saturday Career vs. Brewers (regular season): 1-1, 6.23 ERA (13 IP, 9 ER), 16 H, 6 BB, 5 K in 3 starts; also pitched 6 innings across 2 games in last year's NLDS (allowed 1 run) Misiorowski (8-3, 1.45 ERA) is making his 16th start. He has a 0.75 WHIP, 2.2 BB/9 and 13.4 K/9 in 93 innings. Last start: Loss, 6 IP, 2 ER, 5 H, 1 BB, 7 K in 3-2 loss at Atlanta Braves last Friday Career vs. Cubs (regular season): 1-1, 3.21 ERA (14 IP, 5 ER), 7 H, 6 BB, 20 K in 3 starts; also pitched 7 innings of 1-run ball in the 2025 NLDS Owns a tidy 0.45 ERA since the beginning of May; that stretch includes pitching 6 scoreless innings vs. Chicago May 19 Cubs at Brewers odds Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:22 a.m. ET. Moneyline (ML): Cubs +220 (bet $100 to win $220) | Brewers -270 (bet $270 to win $100) Cubs +220 (bet $100 to win $220) | Brewers -270 (bet $270 to win $100) Run line (RL)/Against the spread (ATS): Cubs +1.5 (-102) | Brewers -1.5 (-118) Cubs +1.5 (-102) | Brewers -1.5 (-118) Over/Under (O/U): 7.5 (O: +100 | U: -122) Slide into: BaseballHQ.com for your fantasy baseball news. For decades, BHQ has been helping players just like you win! BHQ offers full-season subscriptions. Sign up today! Cubs at Brewers picks and predictions Prediction Brewers 5, Cubs 3 No interest; PASS. The Brewers have won 4 straight series meetings and 7 of the last 9. All 7 of those Milwaukee triumphs were by multiple runs. Prior to his solid start in his last, Rea had allowed 11 runs in his previous 9 1/3 IP. Misiorowski, the MLB ERA leader, has filed a 2.35 ERA, 0.90 WHIP at home over 2025-26. He has a superior fastball, and while Chicago has a good offense it does hit fastballs at an impressive clip. The Brewers have an overall bullpen edge, and that advantage gets magnified with several key Cubs relievers being in fatigue territory when it comes to the bullpen budget. Peg the BREWERS -1.5 (-118) as being worth a partial-unit play. The Over is 6-1 in Chicago's last 7 games. The last 12 series meetings in Milwaukee have seen the Over go 8-3-1. Chicago and Milwaukee both own top-10 OPS figures, and both have improved numbers with the bats this month. Mix in both bullpens being on a bit of a slide over recent weeks, and the Cubs not being on their front foot when it comes to reliever availability at the back end. The OVER 7.5 (+100) has value. For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow SportsbookWire on Twitter/X and like us on Facebook.